Can Cannabidiol Help Prevent and Treat Gastrointestinal Disorders? Insights from Experts

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Numerous individuals look for a “cannabis store near me” to obtain marijuana, whether for therapeutic purposes or recreational enjoyment. Many are aware that cannabis products can potentially aid in alleviating symptoms like anxiety, depression, pain, nausea, and vomiting. Have you ever thought about its impact on gastrointestinal disorders?

Key Takeaways:

• Cannabinoids in the plant interact through the endocannabinoid system in the GI tract.
• cannabis and pain medications can assist in managing Irritable Bowel Syndrome symptoms.
• BudsByMail Canada cannabis serves various purposes, but is predominantly recognized for its recreational and medical uses.

Gastrointestinal Disorders and cannabis Plant

The dietary impacts of nutraceuticals on gastrointestinal (GI) health are widely recognized. Certain diets have the potential to prevent or alleviate various GI conditions. Researchers have identified, isolated, and assessed the food components responsible for these effects.

Among the plant-derived nutraceuticals that may benefit GI disorders are those sourced from cannabis. Cannabis refers to preparations derived from the cannabis Sativa plant, a fragrant annual flowering herb.

John M. McPartland concluded in a scientific review that the Cannabaceae family includes the genera Cannabis, Humulus, and Celtis. Within the cannabis genus, sativa consists of three varieties: Sativa, Indica, and Ruderalis. Notably, the cannabis sativa variety serves multiple functions, such as fiber production, oil extraction from seeds, and primarily, recreational or medicinal uses.

The Impact of the Plant

Receptors and ligands of the endocannabinoid system are present in various areas and systems, both within and outside the GI tract, which are important for regulating GI functions. Due to the existence of cannabinoid receptors, cannabinoids, including non-psychoactive phytocannabinoids, play a role in modulating GI functions across health and disease states. The ECS is involved in regulating motility, secretion, epithelial barrier function, and viscerosensitivity.

Irritable Bowel Syndrome (IBS)

IBS has numerous contributing factors and affects approximately 10–20% of individuals in developed countries. It presents as functional gastrointestinal disturbances without identifiable organic causes.

The enhancement of the antinociceptive properties of cannabinoids in the presence of inflammation highlights the importance of the ECS in visceral hypersensitivity. This insight not only illuminates the mechanisms behind conditions like IBS and other gastrointestinal disorders but also suggests promising therapeutic possibilities for alleviating abdominal and visceral pain.

Cannabinoids alone might not provide substantial relief in diminishing visceral hypersensitivity among IBS sufferers. Investigating combinations with other pain-modulating agents, like opioids, could be a fascinating alternative worth exploring.

Inflammatory Bowel Disease (IBD)

IBD, including Crohn’s disease (CD) and ulcerative colitis (UC), is a complex condition of the GI tract. These illnesses arise from environmental, genetic, and epigenetic influences.

Cannabidiol exhibits notable anti-inflammatory properties across various models of intestinal inflammation in mice and rats, as highlighted in a study published in the Journal of Frontiers in Pharmacology. Both local and systemic administration of CBD demonstrated a dose-dependent improvement in disease indicators:

• Reduction of structural damage
• Mitigation of inflammation-related increases in various cytokines, chemokines, and oxidative stress markers.

A study from the Inflammatory Diseases Journal indicated that the main finding of their research was the challenging tolerability of the botanical extract, with 90% of patients reporting treatment-related adverse effects compared to 48% receiving the placebo.

A trend was observed towards improved quality of life scores and a positive change in patients’ overall impression, according to the per-protocol analysis. The authors speculate that the CBD-rich botanical extract might offer therapeutic benefits to those who can tolerate its effects.

Gastrointestinal Cancer

GI cancers, including colorectal cancer (CRC), remain among the most frequently diagnosed conditions in the general population.

Various studies have demonstrated CBD’s antiproliferative effects in colorectal cancer models. CBD can protect DNA from oxidative stress, boost endocannabinoid levels, and inhibit colorectal cancer cell proliferation in vitro.

The confirmation of CBD’s chemopreventive properties was established through investigations using in vivo models focusing on AOM-induced colon cancer. CBD at a dosage of 1 mg/kg led to significant reductions: ACF decreased by 67%, while the number of tumours and polyps fell by 66% and 57%, respectively. Raising the concentration to 5 mg/kg proved effective mainly in preventing polyp formation.

THC induces apoptosis in colorectal cancer cells by activating the CB1 receptor.

Nausea and Vomiting

Positive effects of CBD are observed when combined with THC, as indicated in a study published in the British Journal of Clinical Pharmacology. CBD’s anti-nausea and anti-emetic effects might be linked to the indirect stimulation of somatodendritic 5-HT1A receptors located in the dorsal raphe nucleus. This activation can potentially lead to reduced release of 5-HT in specific forebrain regions.

Gastroesophageal Reflux Disease (GERD)

Cannabinoids inhibit transient LES relaxations via a CB1-dependent mechanism in both dogs and ferrets, as found in a study from the Journal of cannabis and Cannabinoid Research. These findings are significant as transient LES relaxations are the primary mechanism causing gastroesophageal reflux disease.

Cannabis Sativa for GI Issues

Conclusion

Numerous studies suggest that the benefits of cannabinoids extend beyond the well-known psychoactive compound THC to include non-psychoactive compounds like CBD and others, which have received comparatively less attention. The cannabis plant affects the GI system by interacting with the ECS to initiate multiple functions that can help in managing symptoms of specific GI conditions.

Frequently Asked Questions

What can you expect when buying from online cannabis stores?

1. Accessing your cannabis products in Canada from an online store opens up numerous options featuring both classic favorites and new offerings.
2. You can expect additional advantages such as special promotions, secure payment methods, and shipping options covering most provinces.
3. Key resources, including a blog section or contact page, are available to provide customers with insights or help during their shopping journey.
4. As part of the purchasing process, you’ll need to verify or confirm your age by presenting identification.
5. Some stores incorporate taxes into their product prices, while others calculate it at checkout.
6. Certain dispensaries accept online payment methods like Interac E-Transfer, while others offer cash on delivery.

What is the measurement unit when buying from a cannabis website?

There are two primary forms of measurement: metric and imperial units. On a cannabis site, you’ll encounter measurements in grams or ounces, which allows you to find products like 3.5 grams or 1/8 ounces.

What distinguishes cannabis for medical use from that used recreationally?

Medical cannabis and recreational cannabis come from the same plant species, yet their differing effects and intended uses differentiate them. Medical cannabis acts as a therapeutic aid for specific health issues, typically containing a higher CBD concentration compared to recreational cannabis.

Are there ready-made joints available in a cannabis store?

Yes. These are available as pre-rolls. Cannabis pre-rolls, or pre-rolled joints and blunts, offer convenient options for those who prefer their cannabis ready to use. The popularity of pre-rolled joints infused with cannabis concentrates is on the rise.

Do cannabis online stores have a physical shop?

Not all online stores have physical locations, allowing you to receive your purchases directly at your doorstep without needing to pick them up from a physical outlet after placing an order online.

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